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Principal Scientist and Research Associate - Organic/Peptide/Scaleup/Antibody Drug Conjugation (ADC)

  • On-site
    • Ahmedabad, Gujarāt, India
  • Chemistry

Job description

Principal Scientist:

  • Lead and manage a multidisciplinary scientific team of 12-15 FTEs ensuring high-quality project delivery.

  • Handle client communications and independently manage technical calls with global stakeholders.

  • Oversee project planning, execution, timelines, and resource allocation.

  • Provide scientific guidance, troubleshooting, and mentoring to team members.

  • Ensure compliance with quality, safety, and organizational standards.

  • Collaborate cross-functionally to support business and operational goals.

Organic Chemist:

  • Hands-on experience in performing chemical reactions from mg to gram scale independently under scientific guidance

  • Strong knowledge of analytical and purification techniques, including NMR, Mass, HPLC, CombiFlash, and column chromatography

  • Skilled in handling reaction setups, glassware assemblies, reagent charging, temperature control, and nitrogen operations

  • Excellent documentation and data management practices with the ability to follow scientific procedures, patents, and experimental instructions accurately

Peptide Chemist:

  • Hands-on expertise in solid-phase and solution-phase peptide synthesis using automated synthesisers like Syro and Liberty CEM

  • Strong experience in peptide purification, characterisation, and analytical techniques, including HPLC, LCMS, and MS

  • Capable of independently handling medium- to large-scale peptide synthesis (1 g to 1 kg scale) with troubleshooting abilities

  • Skilled in laboratory operations, equipment maintenance, SHE compliance, literature review, and accurate experimental documentation

Scaleup Chemist:

  • Experience in process R&D, scale-up synthesis, and purification from gm to kg scale

  • Skilled in handling 50L/100L GLR assemblies and basic technology transfer activities

  • Proficient in 1H NMR, HPLC, and LCMS interpretation

  • Strong project execution and team collaboration skills

Antibody Drug Conjugation Chemist (ADC)

  • Synthesis and purification of complex antibody drug conjugate (ADC) molecules

  • Synthesis of different types of linkers – using natural and unnatural amino acids, PEGs

  • Synthesis of highly potent drug molecules – payloads

  • Purification of complex and large molecules by flash column and HPLC

  • Handling various type chemistry with different payloads

  • Interpretation and characterisation of higher molecular weight compounds

Job requirements

Principal Scientist;

  • PhD/MSc in Organic Chemistry / Medicinal Chemistry or related field.

  • Strong experience in CRO/CDMO research environment.

  • Proven team management experience with exposure to handling multiple projects.

  • Excellent communication and client-facing skills.

  • Ability to drive productivity, scientific excellence, and team development.

Organic Chemist:

  • Master’s in Organic Chemistry with 1-3 years of experience in the CRO Industry
    Strong organisational, project management and problem-solving skills with impeccable multi-tasking abilities.

  • Proactive, highly motivated with a "can do" attitude

  • Exceptional interpersonal skills.

Peptide/Scaleup/Antibody Drug Conjugation (ADC) Chemist:

  • Master’s in Organic Chemistry with a minimum of 2 years and a maximum of 6 years of experience in the CRO/API Industry

  • Adherence to safe practices and procedures

  • Contribution to the development of safety protocols and systems

  • Must be able to prioritize and organize work responsibilities in order to meet deadlines

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